1. Introduction

1. Introduction#

“We make our world significant by the courage of our questions and the depth of our answers.”

— Carl Sagan, in Cosmos (Chapter 12), 1980.

This chapter starts with the clinical background, followed by the challenges in the treatment process in workflow challenges. Next, it discusses the unmet clinical needs, and ends with the research hypothesis and the structure of the thesis. New terms are explained in Chapter \ref{ChapterBackground}, which readers may skip to go directly to the clinical needs in Part \ref{validationPart}, technical contributions in Part \ref{technicalPart}, and proof-of-concept experiments in Part \ref{pocPart}. A reading guide is shown in Figure \ref{fig:1.4.2structureOfThesis}.

1.1 Clinical Background#

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Motivation: Glioblastoma Treatment#

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Radiotherapy: an Essential Component#

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1.2 Workflow Challenges#

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Variability in Clinical Contouring Practice#

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Time-consuming Plan Optimization Process#

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1.3 Unmet Clinical Needs#

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Current Approaches to Contour Quality Assurance#

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Motivating Dosimetric Contour Quality Assurance#

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1.4 Hypothesis, Contributions, and Structure#

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Hypothesis and Aims#

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Research Contributions#

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Thesis Structure#

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Contents