# 1. Introduction

"We make our world significant by the courage of our questions and the depth of our answers."

— Carl Sagan, in Cosmos (Chapter 12), 1980.


This chapter starts with the [clinical background](#clinical-background), followed by the challenges in the treatment process in [workflow challenges](#workflow-challenges). Next, it discusses the [unmet clinical needs](#unmet-clinical-needs), and ends with the research [hypothesis and the structure of the thesis](#hypothesis-contributions-and-structure). New terms are explained in Chapter \ref{ChapterBackground}, which readers may skip to go directly to the clinical needs in Part \ref{validationPart}, technical contributions in Part \ref{technicalPart}, and proof-of-concept experiments in Part \ref{pocPart}. A reading guide is shown in Figure \ref{fig:1.4.2structureOfThesis}.

## 1.1 Clinical Background

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### Motivation: Glioblastoma Treatment

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### Radiotherapy: an Essential Component

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## 1.2 Workflow Challenges

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### Variability in Clinical Contouring Practice

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### Time-consuming Plan Optimization Process

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## 1.3 Unmet Clinical Needs

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### Current Approaches to Contour Quality Assurance

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### Motivating Dosimetric Contour Quality Assurance

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## 1.4 Hypothesis, Contributions, and Structure

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### Hypothesis and Aims

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### Research Contributions

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### Thesis Structure

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